NTRK Fusion Testing

Detecting NTRK Fusions in Precision Oncology


The NTRK gene family encodes the TRK family of proteins—oncogenic drivers across multiple tumors in adults and children. NTRK fusions to unrelated genes result in overexpression and permanent activation of the TRK fusion proteins. Detection of NTRK fusions has become a primary need in precision oncology research. Scientific NTRK testing guidelines recommend RNA-based next-generation sequencing (NGS) assays as the preferred method for NTRK fusion detection.


NTRK Fusion Testing Guide

NTRK gene fusions can drive unregulated cell growth and proliferation in a range of cancer types. Recently, this pathway gained significant focus and attention in precision oncology.

Next-Generation Sequencing provides the most comprehensive view across a large number of genes and can identify NTRK gene fusions as well as other relevant alterations, with minimal sample tissue needed.

Download our NTRK Testing Guide and:
  • Discover the key factors for NTRK fusion testing
  • Compare different testing methods for NTRK fusions
  • Learn how to get started with NGS for NTRK testing
  • Find the right solution to meet your needs






PD Dr. med. Spasenija Savic Prince
Attending Pathologist
Institute for Medical Genetics and Pathology, University Hospital Basel, Switzerland

On-Demand Webinar

NTRK Fusion Testing in Lung Cancer

View our free on-demand webinar to learn:
  • Why NTRK fusion testing is becoming important.
  • Different methods of NTRK fusion detection, including their pros and cons based on real data from lung cancer testing.
  • How developments in precision oncology are changing not only cancer care, but also the way we should approach biomarker testing in our laboratories.

Additional Resources

Have questions?  We look forward to speaking with you about bringing NGS to your lab.



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Oncomine NTRK Fusion Testing Solutions

We offer several NGS-based, multi-biomarker assays for clinical research designed to simultaneously detect gene fusions, such as NTRK1, NTRK2 and NTRK3, as well as hundreds of DNA and RNA-based genomic alterations associated with cancer. They include: Oncomine Comprehensive Assay, Oncomine Focus Assay, and the Oncomine Childhood Cancer Research Assay

Explore All Oncomine NGS Solutions


For Research Use Only. Not for use in diagnostic procedures.