Myeloid NGS Panels for Genomic Profiling

More rapid.
More automated.

More complete myeloid genomic profiling
with NGS.

Myeloid Testing should
be fast

Myeloid malignancy samples can be challenging to analyze. They are complex, heterogeneous, and have the potential to proliferate rapidly. To get meaningful genetic insights, you need a rapid and streamlined approach for studying all key mutations.

On-Demand Webinars

Advanced NGS Methods for Molecular Testing of Hematological Malignancies

In an AMP workshop, Dr. Cecilia Yeung discussed the latest advances in the application of rapid NGS for myeloid genomic profiling. She shared analytical data from her lab using the Genexus System and provided an overview of exciting collaborations that are leveraging rapid NGS to advance research in hemato-oncology care.

Cecilia Yeung, MD
Associate Professor,
Fred Hutchinson Cancer Center
Medical Director,
Fred Hutch CLIA laboratories

The Impact of Fast NGS Molecular Profiling in Myeloid Malignancy Research

At EHA 2022, Dr. Dolors Colomer discussed the impact that the Oncomine Myeloid Assay GX had on turnaround times and laboratory efficiency. She presented compelling data on FLT3-ITD, showing 100% concordance between NGS and fragment analysis and the ability to detect low-frequency variants ranging in size from 12–180 bp.

Dolors Colomer, PhD
Head of Hematopathology
Hospital Clinic, IDIBAPS,
University of Barcelona, Spain

Oncomine Myeloid Assay GX V2

The Ion Torrent ™ Oncomine™ Myeloid Assay GX V2 on the Ion Torrent™ Genexus™ System provides a complete next-generation sequencing (NGS) solution that can deliver a comprehensive myeloid mutational report in as little as one day.

Rapid	Automated	Comprehensive	Trusted	Insightful

Go from specimen to report in as little as one day. 6	Process samples with just 20 minutes of hands-on time required. 7	Simultaneously profile 45 key genes (DNA) and 35 fusion drivers (RNA), covering >700 unique fusions. 29	Reliably detect a wide range of variants, including challenging-to-sequence targets like FLT3-ITD. 79	Get an annotated variant report, including links to latest relevant evidence. 99

Profile All Key Myeloid Mutations with one test

Simultaneously interrogate 45 DNA target genes and 35 fusion driver genes (RNA). This broad fusion panel allows you to sequence over 700 unique fusion transcripts. Gene content on the panel has been curated to cover relevant targets for all the major myeloid disorders—AML, MDS, MPN, CML, CMML, and JMML.

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Hot Spot Genes

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Full Genes

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Fusion Drivers

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Expression Genes

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Expression Controls

Complete Coverage of Key Genes

Newly added genes shown in green below.

Detect multiple types of mutations
at once

Myeloid samples frequently harbor mutations in difficult-to-sequence regions of the genome.

The Oncomine Myeloid Assay GX v2 has been carefully engineered to reliably detect all relevant mutations associated with myeloid malignancies, including targets in challenging genes like CEBPA, FLT3, CALR and more.

dna-strands

Single nucleotide variants
Insertions and Deletions
Tandem duplications
Gene fusions

Scientific Posters

Poster: 2022 American Association of Cancer Research (AACR) Meeting

Fully automated sample-to-report NGS workflow for comprehensive genomic profiling of myeloid neoplasm research samples

Sarah Brozio, et al. - Thermo Fisher Scientific

View Poster

Recent Performance Data

AMP 2021 Poster: Development of an automated genomic profiling assay for myeloid malignancies research

View our e-Poster published in the AMP 2021 Digital Experience Program to see recent data using the Oncomine Myeloid Assay GX v2.

View Poster

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It's NGS made easy

A highly integrated workflow lets you go from specimen to report with about 20 minutes of hands-on time required*. It’s never been easier to implement myeloid NGS testing in your lab.

Automate your workflow from specimen to report

Start with any common myeloid specimen type, including whole blood, bone marrow, or peripheral blood leukocytes. From there, the Genexus System integrates and automates nucleic acid extraction, purification, quantification, library preparation, sequencing, analysis and reporting within a single software ecosystem.

All Common Species

Whole Blood

Peripheral Blood Leukocytes (PBLs)

Bone Marrow

Automated Workflow

Nucleic acid extraction and quantification

Library preparation

Sequencing

Reporting & analysis

Annotated Variant Report

Biomarkers linked to relevant evidence from public data sources

Clear And Concise Reports

Ion Torrent Oncomine Reporter is a curated knowledgebase and reporting software that links biomarkers to relevant evidence and enables custom reporting. These tools help simplify the bioinformatics workflow and enable you to focus on finding the biological meaning of your data.

See Sample Report

Additional Resources

Oncomine Myeloid Assay GX V2 Flyer

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Oncomine Myeloid Assay GX V2 Infographic

Oncomine Myeloid Assay GX v2

Watch videos to learn more